low toxicity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T35862	Cucurbit[8]uril		Others
	Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, de...		Others
T21246	Metsulfuron-methyl		Others
	Metsulfuron-methyl is a systemic selective wheat field high-efficiency sulfonylurea herbicide, which mainly controls most broadleaf weeds and grass weeds in wheat fields.		Others
T9193	ACH-000143		Melatonin Receptor , MT Receptor
	ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.		Melatonin Receptor , MT Receptor
T7413	JNJ-5207852		Histamine Receptor
	JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.		Histamine Receptor
T13950	UC-514321		Apoptosis , STAT
	UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.		Apoptosis , STAT
T9050	AG-270		Others , Methionine Adenosyltransferase (MAT)
	AG-270 is an allosteric and orally active inhibitor of MAT2A.		Others , Methionine Adenosyltransferase (MAT)
T8646	URB937		FAAH
	URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).		FAAH
T8418	DCLK1-IN-1		Others
	DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain .		Others
T13974	ZL0580		Epigenetic Reader Domain , HIV Protease
	ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.		Epigenetic Reader Domain , HIV Protease
T10565	BMS-1001 hydrochloride		PD-1/PD-L1
	BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat...		PD-1/PD-L1
T9575	MRTX9768		Histone Methyltransferase
	MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.		Histone Methyltransferase
T7860	SM-324405	SM 324405	TLR
	SM-324405 is an agonist of TLR7.		TLR
T4325	COTI-2	COTI 2,COTI2	Apoptosis , p53
	COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.		Apoptosis , p53
T1115	Doxylamine succinate	Decapryn	Histamine Receptor
	Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ...		Histamine Receptor
T9812	Tubulin inhibitor 24		Microtubule Associated
	Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.		Microtubule Associated
T14919	CDKI-73		Apoptosis , CDK
	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effe...		Apoptosis , CDK
T8822	JNJ-5207852 dihydrochloride		Histamine Receptor
	JNJ-5207852 dihydrochloride is a novel, non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.		Histamine Receptor
T6446	Clevudine	L-FMAU,Levovir	HBV , DNA/RNA Synthesis
	Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...		HBV , DNA/RNA Synthesis
T13692	Ferric maltol	Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate	Others
	Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) is a ferric, non-salt-based oral iron formulation demonstrating improved tolerance in patients with previous intolerance to other iron formulations.		Others
T41116	FV-100	Valnivudine HCl
	FV-100 (Valnivudine HCl) is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.FV-100 is a potent, selective and orally active anti-vaxx-z...